Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic modifiers of MeCP2 function in Drosophila.

PLoS genetics - 5 Sept 2008

Cukier Holly N, Perez Alma M, Collins Ann L, Zhou Zhaolan, Zoghbi Huda Y, Botas Juan

Abstract excerpt

The levels of methyl-CpG-binding protein 2 (MeCP2) are critical for normal post-natal development and function of the nervous system. Loss of function of MeCP2, a transcriptional regulator involved in chromatin remodeling, causes classic Rett syndrome (RTT) as well as other related conditions characterized by autism, learning disabilities, or mental retardation. Increased dosage of MeCP2 also leads to clinically...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Chromatin
Share to Drosophila

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methyl-CpG-Binding Protein 2

Share to Microscopy, Electron, Scanning

Share to Phenotype

Share to Phosphorylation

Share to Serine

Source

Open in PubMed Open full text

Identifiers

PMID: 18773074
DOI: 10.1371/journal.pgen.1000179
PMCID: PMC2518867

Genes

REST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic modifiers of MeCP2 function in Drosophila.PMID 18773074Read ↗

Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3.Semantic proximity Read ↗

The molecular pathology of Rett syndrome: synopsis and update.Semantic proximity Read ↗

Suppressor mutations in <i>Mecp2</i> -null mice reveal that the DNA damage response is key to Rett syndrome pathologySemantic proximity Read ↗

Rett syndrome: a complex disorder with simple roots.Semantic proximity Read ↗

MeCP2 dysfunction in humans and mice.Semantic proximity Read ↗

Suppressor mutations in Mecp2-null mice implicate the DNA damage response in Rett syndrome pathology.Semantic proximity Read ↗

MeCP2 Interacts with the Super Elongation Complex to Regulate TranscriptionSemantic proximity Read ↗

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome.Semantic proximity Read ↗

Rett syndrome: a surprising result of mutation in MECP2.Semantic proximity Read ↗

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2.Semantic proximity Read ↗

Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice.Semantic proximity Read ↗

The relationship of Rett syndrome and MECP2 disorders to autism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.