Article

Immunoglobulin-producing AT2-like cells secrete IgA into the extracellular matrix in pulmonary fibrosis

2021-11-02

Abstract excerpt

Pulmonary fibrosis is an interstitial lung disease that can be caused by various factors. Here, we first observed extensive IgA deposition in the extracellular matrix (ECM) of the lungs of mice with pulmonary fibrosis induced by silica inhalation. Consistent with this phenomenon, spatial transcriptomic sequencing of fresh mouse lung tissues from control mice and model mice showed that Igha transcripts were highly...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 84e750f9-3391-57d7-ac67-76f99011b8a1
DOI: 10.1101/2021.11.01.466742

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immunoglobulin-producing AT2-like cells secrete IgA into the extracellular matrix in pulmonary fibrosisDOI 10.1101/2021.11.01.466742Read

Immunoglobulin-producing AT2-like cells secrete IgA into the extracellular matrix in pulmonary fibrosisSemantic proximity Read

AT2 Cell-Derived IgA Trapped by the Extracellular Matrix and Promoted Pulmonary FibrosisSemantic proximity Read

A spatial multi-omics atlas of the human lung reveals a novel immune cell survival nicheSemantic proximity Read

A spatial multi-omics atlas of the human lung reveals a novel gland-associated immune nicheSemantic proximity Read

Integrated multi-omics analyses reveal the pro-inflammatory and pro-fibrotic pulmonary macrophage subcluster in silicosisSemantic proximity Read

Integrated multi-omics analyses reveal the pro-inflammatory and pro-fibrotic pulmonary macrophage subcluster in silicosisSemantic proximity Read

Single-cell and spatial transcriptomics reveal a stress-induced EMT-like epithelial subset driving immune activation in silica-injured lungSemantic proximity Read

Characteristics of ectopic alveolar basal cells relative to airway basal cells in fibrosisSemantic proximity Read

IgG4 <sup>+</sup> plasma cell enrichment and λ-chain-biased BCR remodeling drive low-grade autoimmunity in chronic obstructive pulmonary diseaseSemantic proximity Read

Dynamic pathological analysis reveals a protective role against skin fibrosis for TREM2-dependent macrophagesSemantic proximity Read

GREM1/PPP2R3A expression in heterogeneous fibroblasts initiates pulmonary fibrosisSemantic proximity Read

Alveolar-Basal Intermediates Drive Pulmonary Fibrosis via Coordination of a Pro-Fibrotic Signaling Niche in SilicosisSemantic proximity Read