Article

Alveolar-Basal Intermediates Drive Pulmonary Fibrosis via Coordination of a Pro-Fibrotic Signaling Niche in Silicosis

2026-03-14

Abstract excerpt

Pulmonary fibrosis is a progressive, terminal disease with high morbidity. Existing therapeutics slow disease progression but do not reverse fibrotic lung remodeling, accentuating the importance of identifying cellular mechanisms that underlie lung fibrosis. Recent literature suggests that alveolar type 2 (AT2) progenitors undergo transition to stressed Krt8 high cells following lung injury. Accumulation of stres...

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Literature Corpus work: df0e5f75-1e1f-51e6-a77f-e13c942e6ac1
DOI: 10.64898/2026.03.11.711170

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