Article
A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase.
Cell cycle (Georgetown, Tex.) - 1 Jul 2012
Gatti Marco, Pinato Sabrina, Maspero Elena, Soffientini Paolo, Polo Simona, Penengo Lorenza
Abstract excerpt
Ubiquitination of histones plays a critical role in the regulation of several processes within the nucleus, including maintenance of genome stability and transcriptional regulation. The only known ubiquitination site on histones is represented by a conserved Lys residue located at the C terminus of the protein. Here, we describe a novel ubiquitin mark at the N-terminal tail of histone H2As consisting of two Lys...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.