Article

Stratified Test Accurately Identifies Differentially Expressed Genes Under Batch Effects in Single-Cell Data

2021-06-09

Abstract excerpt

Analyzing single-cell sequencing data from large cohorts is challenging. Discrepancies across experiments and differences among participants often lead to omissions and false discoveries in differentially expressed genes. We find that the Van Elteren test, a stratified version of the widely used Wilcoxon rank-sum test, elegantly mitigates the problem. We also modified the common language effect size to supplement...

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Literature Corpus work: 5186cc10-943b-557a-98dd-bd6c9d1ed080
DOI: 10.1101/2021.06.08.447617

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