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Fast identification of differential distributions in single-cell RNA-sequencing data with waddR

31 Mar 2021

Abstract excerpt

MOTIVATION: Single-cell gene expression distributions measured by single-cell RNA-sequencing (scRNA-seq) often display complex differences between samples. These differences are biologically meaningful but cannot be identified using standard methods for differential expression. RESULTS: Here, we derive and implement a flexible and fast differential distribution testing procedure based on the 2-Wasserstein...

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PMID: 33792651
DOI: 10.1093/bioinformatics/btab226

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