Article

Time-Dependent Effects of Rapid-Acting Antidepressants in iPSC-Derived Neurons from Treatment-Resistant Depression and Healthy Volunteers

2026-02-12

Abstract excerpt

<title>Abstract</title> <p> Rapid-acting antidepressants like ketamine and serotonergic psychedelics show promise for treatment-resistant depression (TRD), but the molecular mechanisms that contribute to their therapeutic effects remain unclear. Induced pluripotent stem cells (iPSCs) offer a platform to model human cortical neurons and investigate drug effects in a human-relevant system. Here, iPSCs from individ...

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Literature Corpus work: fa5d3a54-a63e-5d78-8749-0ef0456ae773
DOI: 10.21203/rs.3.rs-8733841/v1

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