<tt>neoepiscope</tt> improves neoepitope prediction with multi-variant phasing

Abstract excerpt

<h4>ABSTRACT</h4> The vast majority of tools for neoepitope prediction from DNA sequencing of complementary tumor and normal patient samples do not consider germline context or the potential for co-occurrence of two or more somatic variants on the same mRNA transcript. Without consideration of these phenomena, existing approaches are likely to produce both false positive and false negative results, resulting in a...

Topics

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• Antigens, Neoplasm
• Genome
• Genomics
• Immunotherapy
• Monoclonal and Polyclonal Antibodies Research
• Mutation
• Neoplasms
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

eb3783e7-8abb-5518-846b-3beb0b8dd9c0

DOI

10.1101/418129