Histologically defined intratumoral sequencing uncovers evolutionary cues into conserved molecular events driving gliomagenesis

Abstract excerpt

BACKGROUND: Glioblastoma represents an archetypal example of a heterogeneous malignancy. To understand the diverse molecular consequences of this complex tumor ecology, we analyzed RNA-seq data generated from commonly identified intratumoral structures in glioblastoma enriched using laser capture microdissection. METHODS: Raw gene-level values of fragments per kilobase of transcript per million reads mapped and...

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