Article
Mouse models of human non-small-cell lung cancer: raising the bar.
Cold Spring Harbor symposia on quantitative biology - 1 Jan 2005
Kim C F B, Jackson E L, Kirsch D G, Grimm J, Shaw A T, Lane K, Kissil J, Olive K P, Sweet-Cordero A, Weissleder R, Jacks T
Abstract excerpt
Lung cancer is a devastating disease that presents a challenge to basic research to provide new steps toward therapeutic advances. The cell-type-specific responses to oncogenic mutations that initiate and regulate lung cancer remain poorly defined. A better understanding of the relevant signaling pathways and mechanisms that control therapeutic outcome could also provide new insight. Improved conditional mouse...
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