Article

hENT Inhibition Prevents Pyrimidine-Driven Resistance to DHODH Inhibition in Malignant Rhabdoid Tumors

2026-01-27

Abstract excerpt

Extracranial malignant rhabdoid tumors (ecMRTs) are aggressive pediatric cancers characterized by mutations in genes encoding members of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex, with limited effective treatment options. Metabolic reprogramming, including nucleotide biosynthesis, is a hallmark of cancer that represents a potential therapeutic vulnerability. Previously, we demonstra...

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Literature Corpus work: 846d5456-a8d4-513b-8560-e6c6b93c41b0
DOI: 10.64898/2026.01.25.701565

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