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Article

DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma

9 Aug 2022

Abstract excerpt

Despite intensive therapy, children with high-risk neuroblastoma are at risk of treatment failure. We applied a multiomic system approach to evaluate metabolic vulnerabilities in human neuroblastoma. We combined metabolomics, CRISPR screening, and transcriptomic data across more than 700 solid tumor cell lines and identified dihydroorotate dehydrogenase (DHODH), a critical enzyme in pyrimidine synthesis, as a...

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PMID: 35943801
DOI: 10.1172/jci.insight.153836

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DHODH is an independent prognostic marker and potent therapeutic target in neuroblastomaPMID 35943801Read ↗

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