Article

DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma

2021-09-25

Abstract excerpt

<h4>ABSTRACT</h4> Despite intensive therapy, children with high-risk neuroblastoma are at risk of treatment failure. We applied a pan-cancer, multi-omic system approach to evaluate metabolic vulnerabilities in human neuroblastoma. By combining metabolomics, CRISPR screen and gene expression data from more than 700 solid tumor cell lines, we identified DHODH , a critical enzyme in pyrimidine synthesis, as a poten...

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Literature Corpus work: c601decc-a431-597c-bda4-be661b5a00f0
DOI: 10.1101/2021.09.25.461496

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