SMARCB1 Deficiency in Tumors Confers Vulnerability to H3K27 Demethylase Inhibitors via Autophagy Disruption.

doi:10.1158/0008-5472.CAN-25-3921

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Article

SMARCB1 Deficiency in Tumors Confers Vulnerability to H3K27 Demethylase Inhibitors via Autophagy Disruption.

Cancer research - 15 Sept 2026

Vilarrubi Andrea, Guillén Gabriela, Liu Xiaoyu, Navajas-Chocarro Pablo, Morillas Juan M, Martínez-Romero Anabel, Diaz Cristina A, Pros Eva, Altemir-Hervas Eva, Ezzaanouni Abir, Fernández-Serrano Miranda, Roué Gaël, Gómez Antonio, Castillo Sandra D, Vidal August, Carretero Julián, Martínez-Iniesta Maria, Soriano Aroa, Moreno Lucas, Villanueva Alberto, Sanchez-Cespedes Montse, Romero Octavio A

Abstract excerpt

Inactivation of the Switch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex is a hallmark of multiple human cancers. In this study, we showed that SMARCB1-deficient cells, including highly aggressive pediatric malignant rhabdoid tumors (MRT), display aberrant H3K27ac and H3K27me3 dynamics that confer marked sensitivity to the KDM6A/B inhibitor GSK-J4. This vulnerability was absent in cancers...

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Topics

Humans
Autophagy
SMARCB1 Protein
Animals

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Histone Demethylases

Mice

Rhabdoid Tumor

Pyrimidines

Xenograft Model Antitumor Assays

Cell Line, Tumor

Histones

Enzyme Inhibitors

Mutation

Jumonji Domain-Containing Histone Demethylases

Benzazepines

Source

Open in PubMed

Identifiers

PMID: 42269137
DOI: 10.1158/0008-5472.CAN-25-3921

Genes

SMARCB1
KDM6A
KDM6B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

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