Article

Targeting de novo cholesterol synthesis in rhabdomyosarcoma induces cell cycle arrest and triggers apoptosis through ER stress-mediated pathways

2024-12-20

Abstract excerpt

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, but the outcomes of high-grade RMS patients remain poor, underscoring the critical need for novel therapeutic strategies. Although metabolic pathways in RMS are incompletely characterized, emerging evidence suggests that metabolic adaptations in RMS resemble those in other malignancies. Here, we identify elevated cholesterol biosynthesis dr...

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Literature Corpus work: ea0c1df5-738f-5f93-87e6-fceda053758a
DOI: 10.1101/2024.12.18.628900

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