Article
Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models.
Molecular cancer therapeutics - 1 May 2017
Chan-Penebre Elayne, Armstrong Kelli, Drew Allison, Grassian Alexandra R, Feldman Igor, Knutson Sarah K, Kuplast-Barr Kristy, Roche Maria, Campbell John, Ho Peter, Copeland Robert A, Chesworth Richard, Smith Jesse J, Keilhack Heike, Ribich Scott A
Abstract excerpt
The SWI/SNF complex is a major regulator of gene expression and is increasingly thought to play an important role in human cancer, as evidenced by the high frequency of subunit mutations across virtually all cancer types. We previously reported that in preclinical models, malignant rhabdoid tumors, which are deficient in the SWI/SNF core component INI1 (SMARCB1), are selectively killed by inhibitors of the H3K27...
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