Article

Arc mediates intercellular tau transmission via extracellular vesicles

2024-10-22

Abstract excerpt

Intracellular neurofibrillary tangles that consist of misfolded tau protein 1 cause neurodegeneration in Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Tau pathology spreads cell-to-cell 2 but the exact mechanisms of tau release and intercellular transmission remain poorly defined. Tau is released from neurons as free protein or in extracellular vesicles (EVs) 3–5 but the role of these different re...

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Literature Corpus work: 844e61f0-a176-5a54-b90b-3f48ccdf075b
DOI: 10.1101/2024.10.22.619703

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