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Article

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles.

International journal of molecular sciences - 27 Feb 2018

Guix Francesc X, Corbett Grant T, Cha Diana J, Mustapic Maja, Liu Wen, Mengel David, Chen Zhicheng, Aikawa Elena, Young-Pearse Tracy, Kapogiannis Dimitrios, Selkoe Dennis J, Walsh Dominic M

Abstract excerpt

Progressive cerebral accumulation of tau aggregates is a defining feature of Alzheimer's disease (AD). A popular theory that seeks to explain the apparent spread of neurofibrillary tangle pathology proposes that aggregated tau is passed from neuron to neuron. Such a templated seeding process requires that the transferred tau contains the microtubule binding repeat domains that are necessary for aggregation. While...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29495441
DOI: 10.3390/ijms19030663
PMCID: PMC5877524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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