Article

Intra-striatal AAV2.retro administration leads to extensive retrograde transport in the rhesus macaque brain: implications for disease modeling and therapeutic development

2020-01-18

Abstract excerpt

<h4>ABSTRACT</h4> Recently, AAV2.retro, a new capsid variant capable of efficient retrograde transport in brain, was generated in mice using a directed evolution approach. However, it remains unclear to what degree transport will be recapitulated in the substantially larger and more complex nonhuman primate (NHP) brain. Here, we compared the biodistribution of AAV2.retro with its parent serotype, AAV2, in adult m...

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Literature Corpus work: 6bae2177-086d-5c3c-8a65-16cfb2fdd2f7
DOI: 10.1101/2020.01.17.910893

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Intra-striatal AAV2.retro administration leads to extensive retrograde transport in the rhesus macaque brain: implications for disease modeling and therapeutic developmentDOI 10.1101/2020.01.17.910893Read

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