Article
Spike Protein Cleavage-Activation in the Context of the SARS-CoV-2 P681R Mutation: an Analysis from Its First Appearance in Lineage A.23.1 Identified in Uganda.
Microbiology spectrum - 31 Aug 2022
Lubinski Bailey, Frazier Laura E, Phan My V T, Bugembe Daniel L, Cunningham Jessie L, Tang Tiffany, Daniel Susan, Cotten Matthew, Jaimes Javier A, Whittaker Gary R
Abstract excerpt
Based on its predicted ability to affect transmissibility and pathogenesis, surveillance studies have highlighted the role of a specific mutation (P681R) in the S1/S2 furin cleavage site of the SARS-CoV-2 spike protein. Here we analyzed A.23.1, first identified in Uganda, as a P681R-containing virus several months prior to the emergence of B.1.617.2 (Delta variant). We performed assays using peptides mimicking...
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