Article

The SARS-CoV-2 variants associated with infections in India, B.1.617, show enhanced spike cleavage by furin

2021-05-28

Abstract excerpt

The spike (S) glycoprotein of the SARS-CoV-2 virus that emerged in 2019 contained a suboptimal furin cleavage site at the S1/S2 junction with the sequence 681 P RR A R /S 686 . This cleavage site is required for efficient airway replication, transmission, and pathogenicity of the virus. The B.1.617 lineage has recently emerged in India, coinciding with substantial disease burden across the country. Early evide...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 211000ee-c0e7-54bc-8af1-ae1724fed296
DOI: 10.1101/2021.05.28.446163

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The SARS-CoV-2 variants associated with infections in India, B.1.617, show enhanced spike cleavage by furinDOI 10.1101/2021.05.28.446163Read

Intrinsic furin-mediated cleavability of the spike S1/S2 site from SARS-CoV-2 variant B.1.1.529 (Omicron)Semantic proximity Read

Functional evaluation of the P681H mutation on the proteolytic activation the SARS-CoV-2 variant B.1.1.7 (Alpha) spikeSemantic proximity Read

Functional Evaluation of Proteolytic Activation for the SARS-CoV-2 Variant B.1.1.7: Role of the P681H MutationSemantic proximity Read

Spike Protein Cleavage-Activation in the Context of the SARS-CoV-2 P681R Mutation: an Analysis from Its First Appearance in Lineage A.23.1 Identified in Uganda.Semantic proximity Read

Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylationSemantic proximity Read

Spike protein cleavage-activation mediated by the SARS-CoV-2 P681R mutation: a case-study from its first appearance in variant of interest (VOI) A.23.1 identified in UgandaSemantic proximity Read

Spike Protein Cleavage-Activation Mediated by the SARS-CoV-2 P681R Mutation: A Case-Study From Its First Appearance in Variant of Interest (VOI) A.23.1 Identified in UgandaSemantic proximity Read

SARS-CoV-2 spike and its adaptable furin cleavage siteSemantic proximity Read

In SARS-CoV-2 delta variants, Spike-P681R and D950N promote membrane fusion, Spike-P681R enhances spike cleavage, but neither substitution affects pathogenicity in hamstersSemantic proximity Read

SARS-CoV-2 spike P681R mutation, a hallmark of the Delta variant, enhances viral fusogenicity and pathogenicitySemantic proximity Read

Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation.Semantic proximity Read

Functional properties of the spike glycoprotein of the emerging SARS-CoV-2 variant B.1.1.529Semantic proximity Read