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Functional Evaluation of Proteolytic Activation for the SARS-CoV-2 Variant B.1.1.7: Role of the P681H Mutation

2021-07-19

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent causing the COVID-19 pandemic. SARS-CoV-2 B.1.1.7, a variant of concern (VOC) identified in the UK in 2020, contains several mutations including P681H in the spike S1/S2 cleavage site, which is predicted to increase cleavage by furin, potentially impacting the viral cell entry. Here, we studied the role of the P681H mutation in B.1.1.7 cell...

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Literature Corpus work
1bf97390-733d-5d67-9699-ac7642bbf01f
DOI
10.2139/ssrn.3889709
Open publication

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