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Article

PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jun 2011

Billia Filio, Hauck Ludger, Konecny Filip, Rao Vivek, Shen Jie, Mak Tak Wah

Abstract excerpt

Oxidative stress is caused by an imbalance between reactive oxygen species (ROS) production and the ability of an organism to eliminate these toxic intermediates. Mutations in PTEN-inducible kinase 1 (PINK1) link mitochondrial dysfunction, increased sensitivity to ROS, and apoptosis in Parkinson's disease. Whereas PINK1 has been linked to the regulation of oxidative stress, the exact mechanism by which this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21606348
DOI: 10.1073/pnas.1106291108
PMCID: PMC3111326

Genes

PINK1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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