Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FOXO3a-dependent PARKIN negatively regulates cardiac hypertrophy by restoring mitophagy

19 Dec 2022

Abstract excerpt

BACKGROUND: Sustained cardiac hypertrophy often develops maladaptive myocardial remodeling, and eventually progresses to heart failure and sudden death. Therefore, maladaptive hypertrophy is considered as a critical therapeutic target for many heart diseases. Mitophagy, a crucial mechanism in mitochondria quality control and cellular homeostasis, has been implicated in diverse cardiac disorders such as myocardial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cardiac Fibrosis and Remodeling
Share to Cardiovascular Function and Risk Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36539848
DOI: 10.1186/s13578-022-00935-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FOXO3a-dependent PARKIN negatively regulates cardiac hypertrophy by restoring mitophagyPMID 36539848Read ↗

Emerging Role of Mitophagy in the Heart: Therapeutic Potentials to Modulate Mitophagy in Cardiac DiseasesSemantic proximity Read ↗

Phosphatase and tensin homolog‐induced putative kinase 1 and Parkin in diabetic heart: Role of mitophagySemantic proximity Read ↗

Mitophagy in ischemic heart disease: molecular mechanisms and clinical managementSemantic proximity Read ↗

Mitophagy Regulation Following Myocardial InfarctionSemantic proximity Read ↗

Mitophagy in cardiovascular diseases: mechanisms and potential therapiesSemantic proximity Read ↗

Targeting mitophagy in the heart: Exploring the therapeutic potential of MicroRNAsSemantic proximity Read ↗

Sirt3 deficiency exacerbates diabetic cardiac dysfunction: Role of Foxo3A-Parkin-mediated mitophagySemantic proximity Read ↗

Mitochondrial Quality Control in the Maintenance of Cardiovascular Homeostasis: The Roles and Interregulation of UPS, Mitochondrial Dynamics and MitophagySemantic proximity Read ↗

Mitophagy in Diabetic Cardiomyopathy: Roles and MechanismsSemantic proximity Read ↗

Parkin-dependent mitophagy in the heartSemantic proximity Read ↗

PINK1/Parkin-mediated mitophagy in cardiovascular disease: From pathogenesis to novel therapySemantic proximity Read ↗

Ablation of Shank3 alleviates cardiac dysfunction in aging mice by promoting CaMKII activation and Parkin-mediated mitophagySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.