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Article

POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation

29 Oct 2015

Abstract excerpt

Hyperactivation of the transcriptional factor E2F1 occurs frequently in human cancers and contributes to malignant progression. E2F1 activity is regulated by proteolysis mediated by the ubiquitin-proteasome system. However, the deubiquitylase that controls E2F1 ubiquitylation and stability remains undefined. Here we demonstrate that the deubiquitylase POH1 stabilizes E2F1 protein through binding to and...

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PMID: 26510456
DOI: 10.1038/ncomms9704

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