Multi-trait genome-wide association study in 34,394 Chinese women reveals the genetic architecture of plasma metabolites during pregnancy

Abstract excerpt

<h4>Summary</h4> Metabolites are important indicators of individual health and can serve as crucial targets for therapy. However, the genetic basis of many metabolites remains largely unexplored, especially among underrepresented East Asians and during critical periods such as pregnancy. In this study, we utilized genetic information obtained from non-invasive prenatal testing to conduct a genome-wide association...

Topics

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• Gene-Environment Interaction
• Genetic Associations and Epidemiology
• Genome-Wide Association Study
• Mendelian Randomization Analysis
• Metabolome
• Phenotype
• Polymorphism, Single Nucleotide
• Pregnancy

Identifiers and source

Literature Corpus work

840e8e73-cb5a-5339-b1ef-10d3a30085af

DOI

10.1101/2023.11.26.23299022