Article
Genome-wide association analyses of gestational phenotypes identify context-specific genetic effects.
Nature genetics - 1 Aug 2026
Liu Siyang, Zheng Hao, Gu Yuqin, Yang Zijing, Zhen Jianxin, Wei Yuandan, Liu Yanhong, Chen Yanchao, Wan Zijun, Guo Xinxin, Hu Liang, Chen Xiaohang, Li Xiaotian, Qiu Xiu, Huang Shujia, Chen Guo-Bo, Hu Zhibin, Namba Shinichi, Kanai Masahiro, Matsuda Koichi, Okada Yukinori, Zhang Quanfu, Wei Fengxiang
Abstract excerpt
The approximately 40-week gestational period is central to human reproduction, yet the genetic architecture of diverse gestational phenotypes and their links to maternal late-life health remain unclear. In 111 phenotypes from up to 121,579 Chinese pregnancies (median n = 78,535 per phenotype), we identified 4,688 independent genome-wide significant signals, including 1,703 new associations. Gestation-specific...
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