Article
Novel insights into the genetic architecture of pregnancy glycemic traits from 14,744 Chinese maternities.
Cell genomics - 9 Oct 2024
Zhu Huanhuan, Xiao Han, Li Linxuan, Yang Meng, Lin Ying, Zhou Jieqiong, Zhang Xinyi, Zhou Yan, Lan Xianmei, Liu Jiuying, Zeng Jingyu, Wang Lin, Zhong Yuanyuan, Qian Xiaobo, Cao Zhongqiang, Liu Panhong, Mei Hong, Cai Mingzhi, Cai Xiaonan, Tang Zhuangyuan, Hu Liqin, Zhou Rui, Xu Xun, Yang Huanming, Wang Jian, Jin Xin, Zhou Aifen
Abstract excerpt
Glycemic traits are critical indicators of maternal and fetal health during pregnancy. We performed genetic analysis for five glycemic traits in 14,744 Chinese pregnant women. Our genome-wide association study identified 25 locus-trait associations, including established links between gestational diabetes mellitus (GDM) and the genes CDKAL1 and MTNR1B. Notably, we discovered a novel association between fasting...
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