Article
Genome-wide association study of maternal plasma metabolites during pregnancy.
Cell genomics - 9 Oct 2024
Liu Siyang, Yao Jilong, Lin Liang, Lan Xianmei, Wu Linlin, He Xuelian, Kong Nannan, Li Yan, Deng Yuqing, Xie Jiansheng, Zhu Huanhuan, Wu Xiaoxia, Li Zilong, Xiong Likuan, Wang Yuan, Ren Jinghui, Qiu Xuemei, Zhao Weihua, Gao Ya, Chen Yuanqing, Su Fengxia, Zhou Yun, Rao Weiqiao, Zhang Jing, Hou Guixue, Huang Liping, Li Linxuan, Liu Xinhong, Nie Chao, Luo Liqiong, Zhao Mei, Liu Zengyou, Chen Fang, Lin Shengmou, Zhao Lijian, Fu Qingmei, Jiang Dan, Yin Ye, Xu Xun, Wang Jian, Yang Huanming, Wang Rong, Niu Jianmin, Wei Fengxiang, Jin Xin, Liu Siqi
Abstract excerpt
Metabolites are key indicators of health and therapeutic targets, but their genetic underpinnings during pregnancy-a critical period for human reproduction-are largely unexplored. Using genetic data from non-invasive prenatal testing, we performed a genome-wide association study on 84 metabolites, including 37 amino acids, 24 elements, 13 hormones, and 10 vitamins, involving 34,394 pregnant Chinese women, with...
Topics
- Humans
- Female
- Pregnancy
- Genome-Wide Association Study
- Adult
- Mendelian Randomization Analysis
- Polymorphism, Single Nucleotide