Article

Ubiquitin-protein ligase <i>Ubr5</i> cooperates with Hedgehog signalling to promote skeletal tissue homeostasis

2020-12-04

Abstract excerpt

Mammalian Hedgehog (HH) signalling pathway plays an essential role in tissue homeostasis and its deregulation is linked to rheumatological disorders. UBR5 is the mammalian homologue of the E3 ubiquitin-protein ligase Hyd, a negative regulator of the Hh-pathway in Drosophila. To investigate a possible role of UBR5 in regulation of the musculoskeletal system through modulation of mammalian HH signaling, we created...

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Literature Corpus work: 8408be10-e06b-5415-9256-0a32b5bf303c
DOI: 10.1101/2020.12.04.411405

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