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E3 ubiquitin ligases: key regulators of osteogenesis and potential therapeutic targets for bone disorders

15 Aug 2024

Abstract excerpt

Ubiquitination is a crucial post-translational modification of proteins that mediates the degradation or functional regulation of specific proteins. This process participates in various biological processes such as cell growth, development, and signal transduction. E3 ubiquitin ligases play both positive and negative regulatory roles in osteogenesis and differentiation by ubiquitination-mediated degradation or...

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PMID: 39211390
DOI: 10.3389/fcell.2024.1447093

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