Article

Six months of physical inactivity is insufficient to cause chronic kidney disease in C57BL/6J mice

2024-08-30

Abstract excerpt

Chronic kidney disease (CKD) is a progressive disorder marked by a decline in kidney function. Obesity and sedentary behavior contribute to the development of CKD, though mechanisms by which this occurs are poorly understood. This knowledge gap is worsened by the lack of a reliable murine CKD model that does not rely on injury, toxin, or gene deletion to induce a reduction in kidney function. High-fat diet (HFD) f...

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Literature Corpus work: 83e2b9c7-2e7c-551e-90d7-c66774158a22
DOI: 10.1101/2024.08.29.610415

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