Article

Reversible Epigenetic Alterations Regulate Class I HLA Loss in Prostate Cancer

2021-11-11

Abstract excerpt

<title>Abstract</title> <p>Downregulation of HLA class I (HLA-I) impairs immune recognition and surveillance in prostate cancer and may underlie the ineffectiveness of checkpoint blockade. However, the molecular mechanisms regulating HLA-I loss in prostate cancer have not been fully explored. Here, we conducted a comprehensive analysis of HLA-I genomic, epigenomic and gene expression alterations in primary and me...

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Literature Corpus work: 83d5492e-0d09-5048-aa98-242adecd2353
DOI: 10.21203/rs.3.rs-894353/v1

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