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Epigenetic modulation in cancer immunotherapy

11 Jun 2017

Abstract excerpt

The success of immune checkpoint inhibitors in cancer immunotherapy has been widely heralded. However many cancer patients do not respond to immune checkpoint therapy and some relapse due to acquired tumor resistance. Epigenetic targeting may be beneficial in cancer immunotherapy by reversing immune avoidance and escape mechanisms employed by cancer cells, as well as by modulating immune cell differentiation and...

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PMID: 28609681
DOI: 10.1016/j.coph.2017.05.006

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