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Article

Reversible epigenetic alterations regulate class I HLA loss in prostate cancer

1 Sept 2022

Abstract excerpt

Abstract Downregulation of HLA class I (HLA-I) impairs immune recognition and surveillance in prostate cancer and may underlie the ineffectiveness of checkpoint blockade. However, the molecular mechanisms regulating HLA-I loss in prostate cancer have not been fully explored. Here, we conducted a comprehensive analysis of HLA-I genomic, epigenomic and gene expression alterations in primary and metastatic human...

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Share to Epigenetics and DNA Methylation
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PMID: 36050516
DOI: 10.1038/s42003-022-03843-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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