Article

TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits

2019-06-14

Abstract excerpt

<h4>ABSTRACT</h4> The TrkB receptor is critical for the control of energy balance, as mutations in its gene ( NTRK2 ) lead to hyperphagia and severe obesity in humans and mice. The main neural substrate mediating the appetite-suppressing activity of TrkB, however, remains unknown. Here, we demonstrate that selective Ntrk2 deletion within the paraventricular hypothalamus (PVH) leads to severe hyperphagic obesity...

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Literature Corpus work: 83d1026e-8d6f-56b2-8da8-f2b28b3b764f
DOI: 10.1101/671875

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