Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetics-Driven Appetite System Disorders and PI3K/AKT Signaling Activation Mediate a Weight Gain Resistance Phenotype Induced by a High-Fat Diet in Male Rats.

The International journal of eating disorders - 1 Jul 2025

Li Ming-Jie, Du Yao-Xuan, Lan Meng-Ning, Ye Lu-Yi, Xu Yu, Liu Yue, Wu Yi-Xiao, Xia Hai-Yang, Zhang Hua-Yue, Guo Min, Yang Zi-Long, Wu Zheng-Jun, Zheng Hua-Jun

Abstract excerpt

OBJECTIVE: Some patients with anorexia nervosa (AN) exhibit an aversion to high-fat food. The hypothalamus plays a crucial role in feeding behavior. This study investigated the role of epigenetic modifications in the hypothalamus of male rats exhibiting a weight gain resistance (WR) phenotype induced by a high-fat diet (HFD). METHOD: Male Sprague-Dawley (SD) rats were divided into normal diet (ND) and HFD groups...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Appetite
Share to Diet, High-Fat

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Hypothalamus

Share to Phosphatidylinositol 3-Kinases

Share to Proto-Oncogene Proteins c-akt

Share to Rats, Sprague-Dawley

Share to Weight Gain

Source

Identifiers

PMID: 40237130
DOI: 10.1002/eat.24442

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetics-Driven Appetite System Disorders and PI3K/AKT Signaling Activation Mediate a Weight Gain Resistance Phenotype Induced by a High-Fat Diet in Male Rats.PMID 40237130Read ↗

Diet‐induced DNA methylation within the hypothalamic arcuate nucleus and dysregulated leptin and insulin signaling in the pathophysiology of obesitySemantic proximity Read ↗

DNA Methylation in the Hypothalamic Feeding Center and ObesitySemantic proximity Read ↗

[The Update of Obesity Syndrome: Molecular Mechanism, Pathophysiology and Therapies. Topics: I. Recent Topics on Diagnosis and Pathophysiology of the Obesity Syndrome; 5. Feeding regulatory substances and obesity].Semantic proximity Read ↗

Identification of novel candidate neural genes for diet-induced obesity in outbred heterogeneous stock ratsSemantic proximity Read ↗

Obesity in Prader-Willi syndrome: physiopathological mechanisms, nutritional and pharmacological approaches.Semantic proximity Read ↗

Unraveling the brain regulation of appetite: lessons from genetics.Semantic proximity Read ↗

A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi SyndromeSemantic proximity Read ↗

Sex specific effect of ATPase inhibitory factor 1 on body weight: studies in high fat diet induced obese mice and genetic association studies in humans.Semantic proximity Read ↗

Molecular mechanisms underlying anorexia nervosa: focus on human gene association studies and systems controlling food intake.Semantic proximity Read ↗

High-Fat Diet Induces Epigenetic and Metabolic Changes in Kisspeptin Neurons in Association with Obesity and Male Secondary HypogonadismSemantic proximity Read ↗

Weight Loss after Gastric Bypass Surgery in Human Obesity Remodels Promoter MethylationSemantic proximity Read ↗

Untitled literature recordSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.