Article
Appetite enhancement and weight gain by peripheral administration of TrkB agonists in non-human primates.
PloS one - 2 Apr 2008
Lin John C, Tsao David, Barras Paul, Bastarrachea Raul A, Boyd Bob, Chou Joyce, Rosete Rodnie, Long Hua, Forgie Alison, Abdiche Yasmina, Dilley Jeanette, Stratton Jennifer, Garcia Carlos, Sloane David L, Comuzzie Anthony G, Rosenthal Arnon
Abstract excerpt
Loss of function mutations in the receptor tyrosine kinase TrkB pathway resulted in hyperphagia and morbid obesity in human and rodents. Conversely, peripheral or central stimulation of TrkB by its natural ligands BDNF or NT4 reduced body weight and food intake in mice, supporting the idea that TrkB is a key anorexigenic signal downstream of the melanocortin-4 receptor (Mc4r) system. Here we show that in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.