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Article

Proteochemometrics mapping of the interaction space for retroviral proteases and their substrates.

Bioorganic & medicinal chemistry - 15 Jul 2009

Kontijevskis Aleksejs, Petrovska Ramona, Yahorava Sviatlana, Komorowski Jan, Wikberg Jarl E S

Abstract excerpt

Understanding the complex interactions of retroviral proteases with their ligands is an important scientific challenge in efforts to achieve control of retroviral infections. Development of drug resistance because of high mutation rates and extensive polymorphisms causes major problems in treating the deadly diseases these viruses cause, and prompts efforts to identify new strategies. Here we report a...

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Identifiers

PMID: 19539482
DOI: 10.1016/j.bmc.2009.05.045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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