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Article

CLEC12A and CD33 coexpression as a preferential target for pediatric AML combinatorial immunotherapy

23 Oct 2020

Abstract excerpt

Emerging immunotherapies such as chimeric antigen receptor T cells have advanced the treatment of acute lymphoblastic leukemia. In contrast, long-term control of acute myeloid leukemia (AML) cannot be achieved by single lineage-specific targeting while sparing benign hematopoiesis. In addition, heterogeneity of AML warrants combinatorial targeting, and several suitable immunotargets (HAVCR2/CD33 and...

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PMID: 33094319
DOI: 10.1182/blood.2020006921

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