Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SUMO-1 immunoreactivity co-localizes with phospho-Tau in APP transgenic mice but not in mutant Tau transgenic mice.

Neuroscience letters - 15 Aug 2008

Takahashi Kaoru, Ishida Mami, Komano Hajime, Takahashi Hiroshi

Abstract excerpt

Sumoylation is a post-translational modification process that is supposed to be implicated in the pathogenesis of several neurodegenerative diseases. Recently, the microtubule-associated protein Tau was identified as a target for sumoylation in the analysis of the transfected cells. We investigated the localization of SUMO-1 protein in APP transgenic mice and mutant Tau transgenic mice, and found that SUMO-1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Protein Precursor
Share to Brain
Share to Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Mutation

Share to Phosphorylation

Share to SUMO-1 Protein

Share to tau Proteins

Source

Identifiers

PMID: 18586401
DOI: 10.1016/j.neulet.2008.06.012

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SUMO-1 immunoreactivity co-localizes with phospho-Tau in APP transgenic mice but not in mutant Tau transgenic mice.PMID 18586401Read ↗

SUMO2 Protects Against Tau-induced Synaptic and Cognitive DysfunctionSemantic proximity Read ↗

SUMO-1 interacts with mutant ataxin-1 and colocalizes to its aggregates in Purkinje cells of SCA1 transgenic mice.Semantic proximity Read ↗

Age-related changes of protein SUMOylation balance in the AÎ²PP Tg2576 mouse model of Alzheimer's diseaseSemantic proximity Read ↗

Proteomics analysis of the neurodegeneration in the brain of tau transgenic mice.Semantic proximity Read ↗

Direct and/or Indirect Roles for SUMO in Modulating Alpha-Synuclein ToxicitySemantic proximity Read ↗

Increased phosphorylation of tau and synaptic protein loss in the aged transgenic mice expressing familiar Alzheimer's disease-linked presenilin 1 mutation.Semantic proximity Read ↗

Increased tau phosphorylation but absence of formation of neurofibrillary tangles in mice double transgenic for human tau and Alzheimer mutant (M146L) presenilin-1.Semantic proximity Read ↗

SUMO modification of Huntingtin and Huntington's disease pathology.Semantic proximity Read ↗

Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes.Semantic proximity Read ↗

Mutant ubiquitin decreases amyloid β plaque formation in a transgenic mouse model of Alzheimer's disease.Semantic proximity Read ↗

Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules.Semantic proximity Read ↗

Transglutaminase 1 and its regulator tazarotene‐induced gene 3 localize to neuronal tau inclusions in tauopathiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.