Article

RAN translation of the expanded CAG repeats in the SCA3 disease context

2020-05-07

Abstract excerpt

<h4>ABSTRACT</h4> Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder caused by a CAG repeat expansion in the ATXN3 gene encoding the ataxin-3 protein. Despite extensive research the exact pathogenic mechanisms of SCA3 are still not understood in depth. In the present study, to gain insight into the toxicity induced by the expanded CAG repeats in SCA3, we comprehensively investigated...

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Literature Corpus work: 83af29ce-c619-5318-be78-a4144675d0cf
DOI: 10.1101/2020.05.07.082354

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