Article

Mechanism of <i>ATXN8OS</i> CTA/CTG repeat-associated non-AUG translation revealed by approaches ranging from cell-free translation to live-cell imaging

2026-01-27

Abstract excerpt

<h4>ABSTRACT</h4> Microsatellite repeat expansions contribute to the pathogenesis of many neurodegenerative disorders. In spinocerebellar ataxia type 8 (SCA8), abnormal expansion of CTA/CTG repeats in the 3′ untranslated region of the ATXN8OS ( ATXN8 Opposite Strand) gene has been implicated in disease pathology. Although the occurrence of repeat-associated non-AUG (RAN) translation from the ATXN8 transcript h...

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Literature Corpus work: 4829195c-0f12-55b4-88f0-db007f780698
DOI: 10.64898/2026.01.25.700793

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