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Article

Exosome-mediated stable epigenetic repression of HIV-1

20 Sept 2021

Abstract excerpt

Human Immunodeficiency Virus (HIV-1) produces a persistent latent infection. Control of HIV-1 using combination antiretroviral therapy (cART) comes at the cost of life-shortening side effects and development of drug-resistant HIV-1. An ideal and safer therapy should be deliverable in vivo and target the stable epigenetic repression of the virus, inducing a stable "block and lock" of virus expression. Towards this...

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PMID: 34545097
DOI: 10.1038/s41467-021-25839-2

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