Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease

Abstract excerpt

The long interspersed nuclear element-1 (LINE-1 or L1) retrotransposon is the only active autonomously replicating retrotransposon in the human genome. While most of the approximately 500,000 L1 copies are no longer able to propagate, those that retain activity can harm the cell by creating mutations, generating DNA damage, and triggering the expression of inflammatory factors such as the host interferon anti-vira...

Topics

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• Apoptosis
• Cell Proliferation
• Genome, Human
• HeLa Cells
• Long Interspersed Nucleotide Elements
• Mutation
• Retroelements
• RNA

Identifiers and source

Literature Corpus work

83471237-98a7-57fb-ba69-6d4e3819baff

DOI

10.1101/2022.12.29.522256