Article

Polygenic risk prediction and <i>SNCA</i> haplotype analysis in a Latino Parkinson’s disease cohort

2021-11-11

Abstract excerpt

<h4>Background</h4> Large-scale Parkinson’s disease (PD) genome-wide association studies (GWAS) and meta-analyses have, until recently, only been conducted on subjects with European-ancestry. Consequently, polygenic risk scores (PRS) constructed using PD GWAS data are likely to be less predictive when applied to non-European cohorts. <h4>Methods</h4> Using GWAS data from Nalls et al. 2019, we constructed a PD PRS...

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Literature Corpus work: 832c8fd0-e567-5581-a389-77cf1851c8b5
DOI: 10.1101/2021.11.09.21265082

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