Characterizing the Genetic Architecture of Parkinson's Disease in Latinos.

doi:10.1002/ana.26153

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Article

Characterizing the Genetic Architecture of Parkinson's Disease in Latinos.

Annals of neurology - 1 Sept 2021

Loesch Douglas P, Horimoto Andrea R V R, Heilbron Karl, Sarihan Elif I, Inca-Martinez Miguel, Mason Emily, Cornejo-Olivas Mario, Torres Luis, Mazzetti Pilar, Cosentino Carlos, Sarapura-Castro Elison, Rivera-Valdivia Andrea, Medina Angel C, Dieguez Elena, Raggio Victor, Lescano Andres, Tumas Vitor, Borges Vanderci, Ferraz Henrique B, Rieder Carlos R, Schumacher-Schuh Artur, Santos-Lobato Bruno L, Velez-Pardo Carlos, Jimenez-Del-Rio Marlene, Lopera Francisco, Moreno Sonia, Chana-Cuevas Pedro, Fernandez William, Arboleda Gonzalo, Arboleda Humberto, Arboleda-Bustos Carlos E, Yearout Dora, Zabetian Cyrus P, Cannon Paul, Thornton Timothy A, O'Connor Timothy D, Mata Ignacio F

Abstract excerpt

OBJECTIVE: This work was undertaken in order to identify Parkinson's disease (PD) risk variants in a Latino cohort, to describe the overlap in the genetic architecture of PD in Latinos compared to European-ancestry subjects, and to increase the diversity in PD genome-wide association (GWAS) data. METHODS: We genotyped and imputed 1,497 PD cases and controls recruited from nine clinical sites across South America....

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PMID: 34227697
DOI: 10.1002/ana.26153
PMCID: PMC8457043

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