Article
Polygenic risk prediction and SNCA haplotype analysis in a Latino Parkinson's disease cohort.
Parkinsonism & related disorders - 1 Sept 2022
Loesch Douglas P, Horimoto Andrea R V R, Sarihan Elif Irem, Inca-Martinez Miguel, Mason Emily, Cornejo-Olivas Mario, Torres Luis, Mazzetti Pilar, Cosentino Carlos, Sarapura-Castro Elison, Rivera-Valdivia Andrea, Medina Angel C, Dieguez Elena, Raggio Victor, Lescano Andres, Tumas Vitor, Borges Vanderci, Ferraz Henrique B, Rieder Carlos R, Schumacher-Schuh Artur, Santos-Lobato Bruno L, Velez-Pardo Carlos, Jimenez-Del-Rio Marlene, Lopera Francisco, Moreno Sonia, Chana-Cuevas Pedro, Fernandez William, Arboleda Gonzalo, Arboleda Humberto, Arboleda-Bustos Carlos E, Yearout Dora, Zabetian Cyrus P, Thornton Timothy A, Mata Ignacio F, O'Connor Timothy D
Abstract excerpt
BACKGROUND: Large-scale Parkinson's disease (PD) genome-wide association studies (GWAS) have, until recently, only been conducted on subjects with European-ancestry. Consequently, polygenic risk scores (PRS) constructed using PD GWAS data are likely to be less predictive when applied to non-European cohorts. METHODS: Using GWAS data from the largest study to date, we constructed a PD PRS for a Latino PD cohort...
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