Article

Variation in protein coding genes identifies information flow as a contributor to animal complexity

2019-06-21

Abstract excerpt

Across the metazoans there is a trend towards greater organismal complexity. How complexity is generated, however, is uncertain. Since C.elegans and humans have approximately the same number of genes, the explanation will depend on how genes are used, rather than their absolute number. Functional diversity is a measure that quantifies the isoforms, domains and paralogues of a gene. In this paper we determine func...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 71fe3ad8-66ae-5937-a567-a13e1b494233
DOI: 10.1101/679456

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Variation in protein coding genes identifies information flow as a contributor to animal complexityDOI 10.1101/679456Read

Relating protein functional diversity to cell type number identifies genes that determine dynamic aspects of chromatin organisation as potential contributors to organismal complexity.Semantic proximity Read

The landscape of gene loss and missense variation across the mammalian tree informs on gene essentialitySemantic proximity Read

Duplicate gene enrichment and expression pattern diversification in multicellularity.Semantic proximity Read

The shrinking human protein coding complement: are there now fewer than 20,000 genes?Semantic proximity Read

<i>Diviner</i> uncovers hundreds of novel human (and other) exons though comparative analysis of proteinsSemantic proximity Read

A gene-coexpression network for global discovery of conserved genetic modules.Semantic proximity Read

Whole-body gene expression atlas of an adult metazoanSemantic proximity Read

Uncovering the translatome impact of transcriptome induced diversity in eukaryotes: framework and innovative insightsSemantic proximity Read

The relationship between gene isoform multiplicity, number of exons and protein divergence.Semantic proximity Read

An information content principle explains regulatory patterns of gene expression across human tissuesSemantic proximity Read

The animal in the genome: comparative genomics and evolution.Semantic proximity Read

Darwinian genomics and diversity in the tree of life.Semantic proximity Read