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Article

How to overcome the ATRA resistance with the 9aaTAD activation domains in retinoic acid receptors

2018-04-10

Abstract excerpt

In higher metazoa, the nuclear hormone receptors activate transcription trough their specific adaptors, nuclear hormone receptor cofactors NCoA, which are surprisingly absent in lower metazoa. In this study, we demonstrated that the 9aaTAD from NHR-49 receptor activates transcription as a small peptide. We showed, that the 9aaTAD domains are conserved in the human nuclear hormone receptors including HNF4, RARa, VD...

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Literature Corpus work
f9501969-3b24-55a1-9351-67017344e258
DOI
10.1101/298646
Open publication

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How to overcome the ATRA resistance with the 9aaTAD activation domains in retinoic acid receptorsDOI 10.1101/298646
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